Title: Quantification of Uncertainties in high speed fluid flow simulations Abstract: Numerical simulation of fluid flows is a key ingredient in the aerodynamic design of high speed flying vehicles. Uncertainties in the atmospheric environment, geometrical imperfections and operating conditions, can have a strong impact on the overall performance but are rarely quantified. The recent development of efficient uncertainty propagation methods has created the opportunity to augment the design process with a rigorous evaluation of the confidence in the numerical predictions. The talk will introduce the PSAAP Center at Stanford, which is focused on the simulations of a hypersonic vehicle. The main difficulty in the computations of these high speed flows is the presence of sharp discontinuities (shocks) and sudden state- transitions; this also creates a challenge for the uncertainty propagation methods. Two approaches based on modification of the stochastic collocation methodology will be introduced. The first is based on the construction of a global interpolant, while the second uses a local decomposition of the parameter space. The current status and the remaining issues will be described. A recent analysis of stochastic Galerkin methods for hyperbolic systems in the presence of discontinuities will also be described.