Title: From deterministic to stochastic, from mesoscale to macroscopic: multiscale modeling of grain growth Abstract: Many problems in science and engineering call for multiscale modeling and simulations. In some applications the main issues are related to efficient computing, in others -- the challenge is gaining further insight into the problem. Multiscale methodology serves for both, which will be illustrated on the example of modeling of grain growth in materials science. The hierachy of models will be discussed: starting with a very detailed deterministic mesoscale model of curvuture driven growth. The coarsest model is a macroscopic stochastic model that describes evolution of distribution functions.