"Stochastic spectral methods for Bayesian inference in inverse problems" Youssef Marzouk Sandia National Laboratories, Livermore, CA The Bayesian approach to inverse problems provides a foundation for inference from noisy and limited data, a natural mechanism for regularization in the form of prior information, and a quantitative assessment of uncertainty in the inverse solution. With computationally intensive forward models such as PDEs, however, the cost of repeated likelihood evaluations may render a Bayesian approach prohibitive. This difficulty is compounded by high dimensionality, as when the unknown is a spatiotemporal field. We present new algorithmic developments for Bayesian inference in this context, showing strong connections with the forward propagation of uncertainty. In particular, we introduce a stochastic spectral formulation that accelerates the Bayesian solution of inverse problems via rapid evaluation of a surrogate posterior. We also pursue dimensionality reduction for the inference of spatiotemporal fields, using truncated Karhunen-Lo�ve representations of Gaussian process priors. These approaches are demonstrated on scalar transport problems arising in contaminant source inversion and in the inference of inhomogeneous transport properties.