Mastery of semiconductor thin films gave us the integrated circuit, optical information storage, flat panel displays and fiber optic communications. On the immediate horizon, thin-film technology is poised to deliver a solid-state replacement for incandescent and fluorescent lighting. These mature and soon-to-be-realized technologies have been made possible by synthesis techniques and boundary conditions that differ markedly from those of bulk materials. Will the next series of solid-state revolutions be derived from mastery of semiconducting nanowires? As in the transition from bulk to thin-film materials, the evolution from thin-films to nanowires (<~100 nm in diameter) involves an increase in the number of confined dimensions, a new spectrum of synthesis techniques, and substantially altered elastic and electronic boundary conditions. In this talk, I will highlight the opportunities and challenges presented by semiconductor nanowires by focusing on three issues: i) the requisite nonequilibrium nature of nanowire synthesis techniques, ii) the challenge of preserving the continuous high-aspect-ratio nanowire morphology through synthesis, processing and integration, and iii) the opportunity to exploit an expanded palate of coherent lattice-mismatched longitudinal heterostructures in energy conversion devices for solid-state cooling and solid-state lighting. Biosketch: Tim Sands holds a joint appointment in Materials Engineering and Electrical & Computer Engineering at Purdue University. Before joining the faculty at Purdue, he was a professor of Materials Science & Engineering at the University of California, Berkeley (1993-2002) and a member of technical staff and research group director at Bell Communications Research (Bellcore) in Red Bank NJ (1984-1993). His current research focuses on enhancing the functionality of microsystems through heterogeneous integration at the nano- and microscales.